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Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine
Hongmei Xu, Xuetao Cao
《医学前沿(英文)》 2011年 第5卷 第4期 页码 323-332 doi: 10.1007/s11684-011-0172-4
Molecular mechanisms of leukemia-associated protein degradation
Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 363-370 doi: 10.1007/s11684-010-0210-7
关键词: protein degradation leukemia chemical biology transcription factors oncoprotein
陈冀胜
《中国工程科学》 2003年 第5卷 第2期 页码 16-19
生物毒素是一类具有重要意义的生物源化学物质,已知化学结构的毒素可达数千种。生物毒素表现出生源、化学结构、作用机制等多方面的多样性。生物毒素研究已发展成为与多种学科交叉的新学科——毒素学,其发展对于生命化学、生源合成化学、化学生物学、化学生态学、医学、药物学、环境科学均有重要意义,对药物创新研究更具积极作用。许多生物毒素可作为临床药物或导向化合物,并可为药物分子设计提供有价值的新药效模型和结构构架,更能为发现药物新作用靶位发挥特殊作用。
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
《医学前沿(英文)》 doi: 10.1007/s11684-023-1044-4
关键词: SARS-CoV-2 COVID-19 cytokine storm interleukin-6 tocilizumab
Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst
Seiichi Taguchi
《化学科学与工程前沿(英文)》 2017年 第11卷 第1期 页码 139-142 doi: 10.1007/s11705-017-1636-0
关键词: synthetic biology enzyme evolutionary engineering polyhydroxyalkanoate
Special issue on “Green chemical process and intensification”
《化学科学与工程前沿(英文)》 2022年 第16卷 第11期 页码 1533-1535 doi: 10.1007/s11705-022-2263-y
《化学科学与工程前沿(英文)》 2022年 第16卷 第6期 页码 775-776 doi: 10.1007/s11705-022-2172-0
MicroRNAs and lung cancers: from pathogenesis to clinical implications
null
《医学前沿(英文)》 2012年 第6卷 第2期 页码 134-155 doi: 10.1007/s11684-012-0188-4
Lung cancer is the leading cause of cancer-related deaths in the US and worldwide. Better understanding of the disease is warranted for improvement in clinical management. Here we summarize the functions of small-RNA-based, posttranscriptional gene regulators, i.e. microRNAs, in the pathogenesis of lung cancers. We discuss the microRNAs that play oncogenic as well as tumor suppressive roles. We also touch on the value of microRNAs as markers for diagnosis, prognosis and the promising field of microRNA-based novel therapies for lung cancers.
Insight of chemical environmental risk and its management from the vinyl chloride accident
《环境科学与工程前沿(英文)》 2023年 第17卷 第4期 doi: 10.1007/s11783-023-1652-x
关键词: Vinyl chloride Combustion Chemical safety management Environmental risk Emerging contaminants
Effects of sulfur on variations in the chemical speciation of heavy metals from fly ash glass
《环境科学与工程前沿(英文)》 2023年 第17卷 第10期 doi: 10.1007/s11783-023-1728-7
● A higher sulfur content reduced the curing rate of Cr in glass.
关键词: Dechlorinated fly ash SO3 Heavy metal Chemical speciation Glass solidification
宋湛谦
《中国工程科学》 2001年 第3卷 第2期 页码 1-6
林产化学工业是将可再生的森林资源经过化学加工生产出各种有用的产品。它是森林资源高效可持续利用的一个重要组成部分。文章介绍我国林产化学工业的现状,并指出今后发展方向,即加强创新研究,开发深加工产品;推进林产化工企业向大型化发展;发展木材制浆造纸和开发木质能源。
Bioinspired and biomimetic membranes for water purification and chemical separation: A review
《环境科学与工程前沿(英文)》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1412-8
•The history of biological and artificial water channels is reviewed.
关键词: Aquaporins Artificial water channels Biomimetic membranes Chemical separation and water purification
Chemical transdifferentiation: closer to regenerative medicine
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 152-165 doi: 10.1007/s11684-016-0445-z
Cell transdifferentiation, which directly switches one type of differentiated cells into another cell type, is more advantageous than cell reprogramming to generate pluripotent cells and differentiate them into functional cells. This process is crucial in regenerative medicine. However, the cell-converting strategies, which mainly depend on the virus-mediated expression of exogenous genes, have clinical safety concerns. Small molecules with compelling advantages are a potential alternative in manipulating cell fate conversion. In this review, we briefly retrospect the nature of cell transdifferentiation and summarize the current developments in the research of small molecules in promoting cell conversion. Particularly, we focus on the complete chemical compound-induced cell transdifferentiation, which is closer to the clinical translation in cell therapy. Despite these achievements, the mechanisms underpinning chemical transdifferentiation remain largely unknown. More importantly, identifying drugs that induce resident cell conversion in vivo to repair damaged tissue remains to be the end-goal in current regenerative medicine.
关键词: cell therapy cell transdifferentiation chemical compounds small molecules tissue regeneration
Computational design of structured chemical products
Faheem Mushtaq, Xiang Zhang, Ka Y. Fung, Ka M. Ng
《化学科学与工程前沿(英文)》 2021年 第15卷 第5期 页码 1033-1049 doi: 10.1007/s11705-020-2002-1
关键词: product design performance ingredients structure manufacturing process framework structured chemical products microstructure design
Hexachlorobutadiene emissions from typical chemical plants
Minxiang Wang, Lili Yang, Xiaoyun Liu, Zheng Wang, Guorui Liu, Minghui Zheng
《环境科学与工程前沿(英文)》 2021年 第15卷 第4期 doi: 10.1007/s11783-020-1352-8
关键词: Hexachlorobutadiene Chemical plant Chlorobenzene Trichloroethylene Tetrachloroethylene
标题 作者 时间 类型 操作
Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine
Hongmei Xu, Xuetao Cao
期刊论文
Molecular mechanisms of leukemia-associated protein degradation
Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,
期刊论文
Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst
Seiichi Taguchi
期刊论文
Special Issue for the Future Chemical Engineering Scholars of Global Chinese Chemical Engineering Symposium
期刊论文
Computational design of structured chemical products
Faheem Mushtaq, Xiang Zhang, Ka Y. Fung, Ka M. Ng
期刊论文